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The number of samples that are necessary for a good parameter estimation does indeed depend on the estimation method. I am not aware of a simple rule of thumb to determine an optimal sample size, but there has been a lot of literature on this topic. A paper that might be a good starting point for a literature search is Van Zandt T. (2000) How to fit a ...


4

Disclaimer: I'm not generally doing experiments where reaction time is the primary DV. But I thought I'd look at this issue and explored RTs from a neuroimaging dataset, and I think the findings are relevant to the question. I think without further qualification, this question doesn't have an answer. Here I've plotted the estimation of reaction time/RT over ...


2

It depends what you mean by a biological mechanism. If you mean that there should be a protein cascade that implements normalization, that doesn't seem plausible, in my opinion. Normalization in probabilistic population codes is just one of many computations that can be performed in a neural system. If you're okay with the notion that there's nothing ...



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