For questions about mathematical and computational neuroscience.

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What leaps in technology would be needed to scan the total state of the human brain?

What technological leaps would be necessary to capture the absolute state of the brain? This would need to include: a representation of each neuron a representation of each neural connection the ...
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1answer
3 views

Generate fMRI from neurotransmitter consumption

As mentioned in this answer, it's possible to generate an fMRI BOLD signal from neurotransmitter consumption. What equation would be appropriate for this use?
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2answers
60 views

What is a good example of a psychological theory that became formalized into neural and computational terms?

As far as I see it the goal of cognitive sciences is to find a description of mental processes in terms of neural computations that can be eventually formalized by a mathematical theory to generate ...
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1answer
43 views

What is the most unified functional model of the hippocampus?

There are many different incremental models of the hippocampus and it's role in learning as shown by a quick search. However, have there been any efforts to combine these various models into a single ...
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1answer
285 views

Is “Biophysics of Computation” still a good book?

Currently I'm studying mathematics (2nd year) and I think I'm pretty into neuroscience. To "test" this, I purchased Principles of Computational Modelling in Neuroscience and am considering to get ...
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1answer
39 views

What models/mechanisms exist for the brain to chain movements together?

Motor Sequence Learning is the study of the cognitive ability to chain various motor sequences together. The most intuitive example of this is learning to play a sequence of notes on a piano. ...
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1answer
57 views

How do neurons limit their input current?

I know that many neurons have an input current-spiking frequency (I-F) relationships, e.g. as seen here. However, all the I-F curves I've encountered show the input current in a fairly small range (...
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1answer
82 views

What are some good references for preprocessing and analysis of the P300 response from EEG data in Python?

I have just started to work on problems in neuroscience on my own. I sought to analyze the P300 response from EEG data because I was trying to understand a Kaggle.com challenge that used it. I found ...
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0answers
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How does the brain encode order of information in sentences/stories?

When memorizing a sentence or a full story: then, how does the brain encode the order of the words of the sentence or the sentences in the story?
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4answers
166 views

Can humans be reduced to a function?

Based on an article by UK Essays, we are nothing more than robots that operate based on our past experience and other factors like amount of neurotransmitters, hormones, and other chemicals, trying to ...
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1answer
54 views

EPSP/IPSP amplitude values?

I'm working with a Hodgkin-Huxley model that receives synaptic inputs from presynaptic neurons. If it receives a spike from an excitatory presynaptic neuron, the voltage of my HH neuron inceases by an ...
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1answer
36 views

Neuronal differences of linguistic statements [closed]

Assuming that the brain (structure) is only constructed using neurons and synapses, then what is the difference between the following linguistic statements from a 'mechanical point of view'? Bob is ...
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3answers
141 views

Is there a neural network model of Pavlovian Learning?

I am trying to find a computer simulation of Pavlovian learning. i.e. an action such as salivation in response to a stimulus such as a bell ringing. Most neural network models I've seen seem to be ...
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1answer
89 views

How can Semantic Pointer Architecture be used to capture dynamical systems?

Most uses of SPA I've seen seem to be representing static systems, such as recognizing digits, categorizing images, rapid variable creation (also called "completing a pattern") and planning a path for ...
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1answer
29 views

How to compare tasks completed by neural architectures objectively?

When I first saw this video of Spaun and the tasks it can complete (solving the Towers of Hanoi problem, completing the Raven matrices), I was really impressed, but then I realized I didn't really ...
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1answer
95 views

How are movements stored in the brain?

The high level flow of information through the brain for the purpose of motor control is well established. It is also known the cerebellum stores many different movements, while also participating in ...
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1answer
63 views

How much of brain power consumption is for information

As previously answered on this site, the brain uses 20W of power. However, how much of this power consumption is for information processing and how much of it is for maintenance of biological ...
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0answers
33 views

Do adversarial neural networks exist in the brain?

A recent development in Artificial Neural Networks for machine learning applications is the use of Adversarial Networks (see this paper for an example). Adversarial Networks is a network architecture ...
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0answers
52 views

Is cortical magnification in the visual system related to synaptic pruning, or is it a separate developmental or learning process?

I'm primarily interested in learning about current computational models that explain cortical magnification in the visual system. With this in mind, my specific questions are: (1) Is this phenomenon ...
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1answer
51 views

Can neuron change from excitatory to inhibitory (end vice versa) over time?

According to this answer a neuron can release only specific type of neurotransmitters at the time, however, could it change over time? For example a neuron that now releases only inhibitory ...
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5answers
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Why would the brain flip the images perceived by your eyes?

The following is a common scientific statement, which you don't have to google long for to find: The eye views images upside-down in the manner of a camera lens, but our brains reinterpret this ...
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Difference between GALIS and NEF/SPA?

The Gated Attractors Learning Instruction Sequences (GALIS) framework, used to solve a card-matching task, as well as the n-back task, appears to be trying to unite high-level symbolic reasoning to ...
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1answer
220 views

Does the human visual system implement (adaptive) histogram equalization?

The human visual system is very good at 'cancelling out' shadows and other lightning effects, and focusing on the contrast in images. A famous example of this is Adelson's checker shadow illusion: ...
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1answer
54 views

Do dissolving myelinated connections explain learning?

In order to understand how we get rid of established habits/behavior: Can myelinated connections be dissolved or are new connections created that bypass those connections?
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0answers
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How does the hippocampus and the “Papez” circuit form a memory?

It is admitted the hippocampus is necessary to the formation of new long term memories. At first, information goes back and forth between various parts of the cortex and the hippocampus. That's how a ...
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How do the motor system and Central Pattern Generators interact?

Central Pattern Generators are populations of neurons found in the spinal chord that assist in the creation of rhythmic movements. See this paper for a recent publication on the topic. How does the ...
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1answer
32 views

Problems with parameterizing neuronal simulation on a limited number of datasets

I'm hoping to contribute to the OpenWorm project by helping their efforts to parameterize the neurons in CElegans so the model elicits biologically realistic behavior. The problem is I've got only ...
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2answers
27 views

Models relating neuron firing to oscillatory dynamics

Many papers published seem to focused on oscillations to characterize synchronisation and communication between different brain areas. For example, this paper from Voytek et. al where communication ...
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0answers
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Creating non-linear neuron model from linear and actual rates

In "Theoretical Neuroscience" by Dayan and Abbott, section 2.2 "Estimating Firing Rates", it describes how by using a linear model in combination with averaged experimental firing rates you can ...
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1answer
39 views

what is the “trial-averaged neural response function”?

i'am currently reading " theoretical neuroscience by dayan abbott" and it says " If we ignore the brief duration of an action potential (about 1 ms), an action potential sequence can be ...
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4answers
117 views

In what ways do our brains use compression?

I am reading a book on information theory and one line in the book states that "Brains are the ultimate compression and communication systems." However, there is no further elaboration on the matter. ...
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1answer
71 views

Is semantic pointer architecture compatible with a predictive coding account of the brain?

Both SPA (Eliasmith et al.) and predictive coding (Friston, Clark, Rao, et al.) seem to have a lot of explanatory power. My understanding of SPA is probably rudimentary, but Eliasmith and others ...
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3answers
61 views

When does the brain 'switch on'? [closed]

I am pursuing Computational Neuro-Science and learning about human Brain. After some reading I got this doubt that when does the brain actually gets switched on? Does it happen right in the mother's ...
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1answer
53 views

A question on synapses

we are looking into running simulations of the nervous system of C. Elegans. It is believed by most people that the worm's nervous system encodes information through graded potentials and/or plateau ...
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0answers
19 views

Influence of LIP on visual cortex

I understand that the lateral intraparietal cortex (LIP) maps various features of targets onto an eye-centric reference frame. I also know that this mapping predicts where visual attention (in the ...
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1answer
9 views

Neuroanatomical mapping of production compilation

ACT-R and Spaun map their production rule system onto the the basal ganglia and thalamus. However, I haven't been able to find how ACT-R maps production rule compilation onto the basal ganglia or ...
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1answer
29 views

Publicly Available NEURON models

NEURON is a software package for simulating neurons and networks in great detail. Although it's quite easy to find papers that use NEURON with a simple Google Scholar search, is there some way to find ...
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1answer
175 views

How long does the trace of a memory last in the brain?

With long-term plasticity one refers to the phenomen by which synapses are modified by neural activity and these modifications last for long times, a day perhaps of the order of days. This phenomenon ...
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1answer
47 views

During synchronized waves oscillation (alpha beta etc…) do neurons fire only once for each wave cycle?

Or can they fire few times then pause and again, firefew times and pause periodically? If the second case happens then do we know if the neurons that fire in synchronity fire the same number of ...
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0answers
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When we say signals go from one cortical area to an other one do we mean they go directly without going through the thalamus for example?

Or is it implied signals always have to go back and forth between the thalamus and the cortex? Or is it possible they do both at the same time? Or maybe for areas next to each others they can go ...
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1answer
51 views

How can neuronal networks with local learning rules predict their future inputs?

Local learning rules like Contrastive Hebbian Learning, XCAL, etc. are based on the idea of strengthening edges when the neurons they connect fire simultaneously. This causes frequent patterns in the ...
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0answers
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How can higher concepts get unrolled with upward and feedback connections differing?

In the neocortex, input patterns are compressed hierarchically. Sensory inputs in the lower levels are combined by higher levels to form abstract concepts. However, there are even more feedback ...
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2answers
48 views

Understanding neuronal firing in the context of Spike Timing Dependent Plasticity

When discussing Spike Timing Dependent Plasticity in neurons, when we say that a neuron fires do we mean it fires only one spike? Or do we still say "the neuron has fired" when a train of n spikes was ...
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1answer
21 views

Limitations of Neural Engineering Framework (NEF)

All frameworks have limitations. Although I ask a lot of questions on this site in regards to the advantages of the Neural Engineering Framework (NEF), there must be significant limitations. What are ...
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1answer
55 views

What is known about the information that's passed upwards within the neocortex?

The neocortex is likely to process sparse representations in a hierarchy with information close to the raw sensor input appearing in lower levels and abstract concepts being appearing in higher levels....
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1answer
96 views

What functional purpose does a cortical column serve?

The Blue Brain project led by Henry Markram focused on simulating cortical columns under the idea they form basic processing units of the brain/cognitive function. What functional purpose does a ...
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0answers
60 views

Increasing pitch perception of the same auditory stimuli

I was trying to work up a small clip of repeating beep sounds I recorded from a mobile game. This series of sounds, when played, gave an unmistakable perception of increasing pitch with every ...
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1answer
27 views

How is memory accounted for in the NEF?

The Neurological Engineering Framework can be used to create systems that use memory in interesting ways. One system (Spaun) is able to memorize (and forget) lists much in the same way as humans do. ...
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0answers
16 views

How does hPES describe STDP?

Spike-Timing-Dependent Plasticity is believed to be how neurons change their connection weights and thus change what functions they are computing. From Towards Biologically Plausible Deep Learning: ...
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4answers
269 views

Is it possible to increase the capacity of human brain like “Lucy”?

I saw the film "Lucy" in 2015. The film says that humans can use 100% percent of the capacity of their brains. According to my personal ideas, the capacity of the brain will changed based on the ...