# Tagged Questions

For questions about mathematical and computational neuroscience.

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### Generate fMRI from neurotransmitter consumption

As mentioned in this answer, it's possible to generate an fMRI BOLD signal from neurotransmitter consumption. What equation would be appropriate for this use?
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### Human brain v/s computer: speed comparison?

We can't compute (speaking of some of the functions a computer can perform ) as fast as a computer. Where does this shortcoming stem from- working memory or clock frequency perhaps comparable to the ...
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### Difference between content-addressable memory and associative memory?

Often when I'm reading theoretical neuroscience publications, such as "Towards an integration of deep learning and neuroscience", as well as "Memory and the Computational Brain", theorists often ...
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### How many possible states does a brain have?

Suppose I have a box, inside of which is a light which can be either on or off: it has exactly two states. Suppose I wanted to take some "snapshot" of the state of this device, and store all the ...
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### What is the role of (why )universal gas constant in Nernst equation?

The Nernst equation is an equation that relates the the total voltage, i.e. the electromotive force, of the full cell at any point in time to the standard electrode potential, temperature, activity, ...
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### Using a Linear Non-linear Cascade with a Non-Random (deterministic) Stimulus

I'm attempting to use a computational model, in particular a linear non-linear cascade (LNP) to encode the spiking of a neuron responding to a thermal stimulus. In a LNP, it assumes that the stimulus ...
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### Neurons - Which Types, How much Inputs/Outputs?

I plan to build a neural network that is as near as possible to a biological one. So I have 2 questions regarding properties of neurons in the brain and their types: What types are there and where ...
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### Neurons - Firing-Rate and Task? [closed]

I plan to build a neural network that is as near as possible to a biological one. So I have 2 questions regarding properties of neurons in the brain and their types: What is the firing rate (average)...
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### Can “fire together, wire together” be undone?

Are new connections continuously forged in the adult human brain, or do we just start all wired together and then prune until we have something we like?
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### References for biologically plausible models of knowledge representation?

I'm looking for references that deal with the issue of how various kinds of semantic knowledge are (or might be) represented neurally. Most of the discussion of this topic seems skewed by social ...
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### Do synapses have special types?

I assume synapses/dendrites/axons are relations which connect one entity/neuron to another, for example: a car is a vehicle: "is" relation Bob has a sister: "has" relation etc. I would just ...
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### What leaps in technology would be needed to scan the total state of the human brain? [closed]

What technological leaps would be necessary to capture the absolute state of the brain? This would need to include: a representation of each neuron a representation of each neural connection the ...
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### What is a good example of a psychological theory that became formalized into neural and computational terms?

As far as I see it the goal of cognitive sciences is to find a description of mental processes in terms of neural computations that can be eventually formalized by a mathematical theory to generate ...
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### What is the most unified functional model of the hippocampus?

There are many different incremental models of the hippocampus and it's role in learning as shown by a quick search. However, have there been any efforts to combine these various models into a single ...
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### Is “Biophysics of Computation” still a good book?

Currently I'm studying mathematics (2nd year) and I think I'm pretty into neuroscience. To "test" this, I purchased Principles of Computational Modelling in Neuroscience and am considering to get ...
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### What models/mechanisms exist for the brain to chain movements together?

Motor Sequence Learning is the study of the cognitive ability to chain various motor sequences together. The most intuitive example of this is learning to play a sequence of notes on a piano. ...
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### How do neurons limit their input current?

I know that many neurons have an input current-spiking frequency (I-F) relationships, e.g. as seen here. However, all the I-F curves I've encountered show the input current in a fairly small range (...
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### What are some good references for preprocessing and analysis of the P300 response from EEG data in Python?

I have just started to work on problems in neuroscience on my own. I sought to analyze the P300 response from EEG data because I was trying to understand a Kaggle.com challenge that used it. I found ...
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### How does the brain encode order of information in sentences/stories?

When memorizing a sentence or a full story: then, how does the brain encode the order of the words of the sentence or the sentences in the story?
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### Can humans be reduced to a function?

Based on an article by UK Essays, we are nothing more than robots that operate based on our past experience and other factors like amount of neurotransmitters, hormones, and other chemicals, trying to ...
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### EPSP/IPSP amplitude values?

I'm working with a Hodgkin-Huxley model that receives synaptic inputs from presynaptic neurons. If it receives a spike from an excitatory presynaptic neuron, the voltage of my HH neuron inceases by an ...
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### Neuronal differences of linguistic statements [closed]

Assuming that the brain (structure) is only constructed using neurons and synapses, then what is the difference between the following linguistic statements from a 'mechanical point of view'? Bob is ...
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### Is there a neural network model of Pavlovian Learning?

I am trying to find a computer simulation of Pavlovian learning. i.e. an action such as salivation in response to a stimulus such as a bell ringing. Most neural network models I've seen seem to be ...
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### How can Semantic Pointer Architecture be used to capture dynamical systems?

Most uses of SPA I've seen seem to be representing static systems, such as recognizing digits, categorizing images, rapid variable creation (also called "completing a pattern") and planning a path for ...
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### How to compare tasks completed by neural architectures objectively?

When I first saw this video of Spaun and the tasks it can complete (solving the Towers of Hanoi problem, completing the Raven matrices), I was really impressed, but then I realized I didn't really ...
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### How are movements stored in the brain?

The high level flow of information through the brain for the purpose of motor control is well established. It is also known the cerebellum stores many different movements, while also participating in ...
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### How much of brain power consumption is for information

As previously answered on this site, the brain uses 20W of power. However, how much of this power consumption is for information processing and how much of it is for maintenance of biological ...
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### Do adversarial neural networks exist in the brain?

A recent development in Artificial Neural Networks for machine learning applications is the use of Adversarial Networks (see this paper for an example). Adversarial Networks is a network architecture ...
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### Is cortical magnification in the visual system related to synaptic pruning, or is it a separate developmental or learning process?

I'm primarily interested in learning about current computational models that explain cortical magnification in the visual system. With this in mind, my specific questions are: (1) Is this phenomenon ...
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### Can neuron change from excitatory to inhibitory (end vice versa) over time?

According to this answer a neuron can release only specific type of neurotransmitters at the time, however, could it change over time? For example a neuron that now releases only inhibitory ...
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### Why would the brain flip the images perceived by your eyes?

The following is a common scientific statement, which you don't have to google long for to find: The eye views images upside-down in the manner of a camera lens, but our brains reinterpret this ...
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### Difference between GALIS and NEF/SPA?

The Gated Attractors Learning Instruction Sequences (GALIS) framework, used to solve a card-matching task, as well as the n-back task, appears to be trying to unite high-level symbolic reasoning to ...
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### Does the human visual system implement (adaptive) histogram equalization?

The human visual system is very good at 'cancelling out' shadows and other lightning effects, and focusing on the contrast in images. A famous example of this is Adelson's checker shadow illusion: ...
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### Do dissolving myelinated connections explain learning?

In order to understand how we get rid of established habits/behavior: Can myelinated connections be dissolved or are new connections created that bypass those connections?
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### How does the hippocampus and the “Papez” circuit form a memory?

It is admitted the hippocampus is necessary to the formation of new long term memories. At first, information goes back and forth between various parts of the cortex and the hippocampus. That's how a ...
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### How do the motor system and Central Pattern Generators interact?

Central Pattern Generators are populations of neurons found in the spinal chord that assist in the creation of rhythmic movements. See this paper for a recent publication on the topic. How does the ...
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### Problems with parameterizing neuronal simulation on a limited number of datasets

I'm hoping to contribute to the OpenWorm project by helping their efforts to parameterize the neurons in CElegans so the model elicits biologically realistic behavior. The problem is I've got only ...
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### Models relating neuron firing to oscillatory dynamics

Many papers published seem to focused on oscillations to characterize synchronisation and communication between different brain areas. For example, this paper from Voytek et. al where communication ...
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### Creating non-linear neuron model from linear and actual rates

In "Theoretical Neuroscience" by Dayan and Abbott, section 2.2 "Estimating Firing Rates", it describes how by using a linear model in combination with averaged experimental firing rates you can ...
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### what is the “trial-averaged neural response function”?

i'am currently reading " theoretical neuroscience by dayan abbott" and it says " If we ignore the brief duration of an action potential (about 1 ms), an action potential sequence can be ...
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### In what ways do our brains use compression?

I am reading a book on information theory and one line in the book states that "Brains are the ultimate compression and communication systems." However, there is no further elaboration on the matter. ...
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### Is semantic pointer architecture compatible with a predictive coding account of the brain?

Both SPA (Eliasmith et al.) and predictive coding (Friston, Clark, Rao, et al.) seem to have a lot of explanatory power. My understanding of SPA is probably rudimentary, but Eliasmith and others ...
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### When does the brain 'switch on'? [closed]

I am pursuing Computational Neuro-Science and learning about human Brain. After some reading I got this doubt that when does the brain actually gets switched on? Does it happen right in the mother's ...
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### A question on synapses

we are looking into running simulations of the nervous system of C. Elegans. It is believed by most people that the worm's nervous system encodes information through graded potentials and/or plateau ...
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### Influence of LIP on visual cortex

I understand that the lateral intraparietal cortex (LIP) maps various features of targets onto an eye-centric reference frame. I also know that this mapping predicts where visual attention (in the ...
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### Neuroanatomical mapping of production compilation

ACT-R and Spaun map their production rule system onto the the basal ganglia and thalamus. However, I haven't been able to find how ACT-R maps production rule compilation onto the basal ganglia or ...
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### Publicly Available NEURON models

NEURON is a software package for simulating neurons and networks in great detail. Although it's quite easy to find papers that use NEURON with a simple Google Scholar search, is there some way to find ...
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### How long does the trace of a memory last in the brain?

With long-term plasticity one refers to the phenomen by which synapses are modified by neural activity and these modifications last for long times, a day perhaps of the order of days. This phenomenon ...