For questions about mathematical and computational neuroscience.

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Can neuron change from excitatory to inhibitory (end vice versa) over time?

According to this answer a neuron can release only specific type of neurotransmitters at the time, however, could it change over time? For example a neuron that now releases only inhibitory ...
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5 views

Difference between GALIS and NEF/SPA?

The Gated Attractors Learning Instruction Sequences (GALIS) framework, used to solve a card-matching task, as well as the n-back task, appears to be trying to unite high-level symbolic reasoning to ...
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1answer
207 views

Does the human visual system implement (adaptive) histogram equalization?

The human visual system is very good at 'cancelling out' shadows and other lightning effects, and focusing on the contrast in images. A famous example of this is Adelson's checker shadow illusion: ...
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4answers
101 views

Can humans be reduced to a function?

Based on an article by UK Essays, we are nothing more than robots that operate based on our past experience and other factors like amount of neurotransmitters, hormones, and other chemicals, trying to ...
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18 views

Analysing ERP (Event-Related Potentials from EEG recordings in fucus on P-300 waves

I am trying to understand how to analyze ERP (Event-Related Potentials) from EEG recordings in fucus on P-300 waves. I have come up with a few questions which I hope you might be able to help with: ...
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How do the motor system and Central Pattern Generators interact?

Central Pattern Generators are populations of neurons found in the spinal chord that assist in the creation of rhythmic movements. See this paper for a recent publication on the topic. How does the ...
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1answer
45 views

How are movements stored in the brain?

The high level flow of information through the brain for the purpose of motor control is well established. It is also known the cerebellum stores many different movements, while also participating in ...
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27 views

How does the hippocampus and the “Papez” circuit form a memory?

It is admitted the hippocampus is necessary to the formation of new long term memories. At first, information goes back and forth between various parts of the cortex and the hippocampus. That's how a ...
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27 views

Problems with parameterizing neuronal simulation on a limited number of datasets

I'm hoping to contribute to the OpenWorm project by helping their efforts to parameterize the neurons in CElegans so the model elicits biologically realistic behavior. The problem is I've got only ...
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2answers
23 views

Models relating neuron firing to oscillatory dynamics

Many papers published seem to focused on oscillations to characterize synchronisation and communication between different brain areas. For example, this paper from Voytek et. al where communication ...
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6 views

Creating non-linear neuron model from linear and actual rates

In "Theoretical Neuroscience" by Dayan and Abbott, section 2.2 "Estimating Firing Rates", it describes how by using a linear model in combination with averaged experimental firing rates you can ...
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1answer
31 views

what is the “trial-averaged neural response function”?

i'am currently reading " theoretical neuroscience by dayan abbott" and it says " If we ignore the brief duration of an action potential (about 1 ms), an action potential sequence can be ...
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49 views

A question on synapses

we are looking into running simulations of the nervous system of C. Elegans. It is believed by most people that the worm's nervous system encodes information through graded potentials and/or plateau ...
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3answers
59 views

When does the brain 'switch on'? [closed]

I am pursuing Computational Neuro-Science and learning about human Brain. After some reading I got this doubt that when does the brain actually gets switched on? Does it happen right in the mother's ...
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1answer
41 views

What is a good example of a psychological theory that became formalized into neural and computational terms?

As far as I see it the goal of cognitive sciences is to find a description of mental processes in terms of neural computations that can be eventually formalized by a mathematical theory to generate ...
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0answers
18 views

Influence of LIP on visual cortex

I understand that the lateral intraparietal cortex (LIP) maps various features of targets onto an eye-centric reference frame. I also know that this mapping predicts where visual attention (in the ...
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1answer
29 views

Publicly Available NEURON models

NEURON is a software package for simulating neurons and networks in great detail. Although it's quite easy to find papers that use NEURON with a simple Google Scholar search, is there some way to find ...
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27 views

When we say signals go from one cortical area to an other one do we mean they go directly without going through the thalamus for example?

Or is it implied signals always have to go back and forth between the thalamus and the cortex? Or is it possible they do both at the same time? Or maybe for areas next to each others they can go ...
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1answer
46 views

During synchronized waves oscillation (alpha beta etc…) do neurons fire only once for each wave cycle?

Or can they fire few times then pause and again, firefew times and pause periodically? If the second case happens then do we know if the neurons that fire in synchronity fire the same number of ...
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10 views

How can higher concepts get unrolled with upward and feedback connections differing?

In the neocortex, input patterns are compressed hierarchically. Sensory inputs in the lower levels are combined by higher levels to form abstract concepts. However, there are even more feedback ...
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2answers
44 views

Understanding neuronal firing in the context of Spike Timing Dependent Plasticity

When discussing Spike Timing Dependent Plasticity in neurons, when we say that a neuron fires do we mean it fires only one spike? Or do we still say "the neuron has fired" when a train of n spikes was ...
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1answer
54 views

What is known about the information that's passed upwards within the neocortex?

The neocortex is likely to process sparse representations in a hierarchy with information close to the raw sensor input appearing in lower levels and abstract concepts being appearing in higher ...
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1answer
18 views

Limitations of Neural Engineering Framework (NEF)

All frameworks have limitations. Although I ask a lot of questions on this site in regards to the advantages of the Neural Engineering Framework (NEF), there must be significant limitations. What are ...
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1answer
42 views

How can neuronal networks with local learning rules predict their future inputs?

Local learning rules like Contrastive Hebbian Learning, XCAL, etc. are based on the idea of strengthening edges when the neurons they connect fire simultaneously. This causes frequent patterns in the ...
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Increasing pitch perception of the same auditory stimuli

I was trying to work up a small clip of repeating beep sounds I recorded from a mobile game. This series of sounds, when played, gave an unmistakable perception of increasing pitch with every ...
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How does hPES describe STDP?

Spike-Timing-Dependent Plasticity is believed to be how neurons change their connection weights and thus change what functions they are computing. From Towards Biologically Plausible Deep Learning: ...
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2answers
112 views

Is there a neural network model of Pavlovian Learning?

I am trying to find a computer simulation of Pavlovian learning. i.e. an action such as salivation in response to a stimulus such as a bell ringing. Most neural network models I've seen seem to be ...
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4answers
230 views

Is it possible to increase the capacity of human brain like “Lucy”?

I saw the film "Lucy" in 2015. The film says that humans can use 100% percent of the capacity of their brains. According to my personal ideas, the capacity of the brain will changed based on the ...
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1answer
49 views

Do dissolving myelinated connections explain learning?

In order to understand how we get rid of established habits/behavior: Can myelinated connections be dissolved or are new connections created that bypass those connections?
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1answer
59 views

Can dendrite spines fire action potential toward the soma?

I am confused about how the signal propagates from the dendrite spines toward the soma. I believe it is commonly taught that the signal diffuses "passively", i.e. electrostatically with no ...
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4answers
111 views

In what ways do our brains use compression?

I am reading a book on information theory and one line in the book states that "Brains are the ultimate compression and communication systems." However, there is no further elaboration on the matter. ...
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55 views

How much of brain power consumption is for information

As previously answered on this site, the brain uses 20W of power. However, how much of this power consumption is for information processing and how much of it is for maintenance of biological ...
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2answers
87 views

Possibility of increasing brain speed

In science fiction stories, we often see the use of virtual reality, a 3d world that allows you to actually 'be' there. The writers often use a pod or helmet to signify the use of some sort of ...
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2answers
111 views

Neural nets for cognition

I recently got into Neural networks. As much as I have understood, the learning process is based on the change in weights according to stimulus and algorithm used in learning. Does this in any way ...
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1answer
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The article “Vector reconstruction from Firing Rates” of Abbott and Salinas

Is anyone familiar with this article? I am reading it, and it is basically very clear. But still, some points are not clear to me. For example, how is equation (7.1) in page 12: $Q_{i,j}^{-1} = ...
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1answer
81 views

link between top-down (bottom-up) processing and cortex layers

What are the relations between top-down and bottom-up processings and the flows of information in the brain? For example, does top-down processing start from some layers and go to lower layers? If so ...
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7 views

What is the limitation of Biosocial Theory developed by Linehan?

Linehan's biosocial theory takes into consideration of the accumulation effect of a stress on individuals, which the Diathesis-stress model could not explain. A predisposition (diathesis) with stress ...
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1answer
7 views

Neuroanatomical mapping of production compilation

ACT-R and Spaun map their production rule system onto the the basal ganglia and thalamus. However, I haven't been able to find how ACT-R maps production rule compilation onto the basal ganglia or ...
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2answers
49 views

Color and shape arriving together in visual system

I know that in the visual cortex there are separate visual pathways for both color and shape. Do these separate pathways imply that human beings become consciously aware of these features separately ...
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1answer
20 views

Can anyone see what is wrong with this implementation of the Pinsky-Rinzel model in Brian2?

Not sure if this is the right place to ask this but I've been attempting to implement the Pinsky-Rinzel model in the Brian2 simulator. I'm basing my implementation off the original article here: ...
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1answer
117 views

How many possible states does a brain have?

Suppose I have a box, inside of which is a light which can be either on or off: it has exactly two states. Suppose I wanted to take some "snapshot" of the state of this device, and store all the ...
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1answer
68 views

Is semantic pointer architecture compatible with a predictive coding account of the brain?

Both SPA (Eliasmith et al.) and predictive coding (Friston, Clark, Rao, et al.) seem to have a lot of explanatory power. My understanding of SPA is probably rudimentary, but Eliasmith and others ...
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1answer
91 views

Interpretation & Actual Result of “10% of your brain” Myth

It is well known that the common myth that an individual only ever uses 10% of their brain is.. well, a myth. I had a question about a possible interpretation of this idea, and a follow-up question ...
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1answer
59 views

How does a human classify or cluster data?

Here, what I mean by DATA are text documents. I am going to do a research on text clustering algorithms by the help of artificial neural networks (ANNs). But first of all I need to know how our brain ...
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0answers
46 views

Why cerebellar input fibers use 2 ways to send a siganl to DCN?

Both groups of input fibers of cerebellum (mossy, climbing) start 2 pathways: 1) project directly to the deep nuclei 2) project to cerebellar cortex, which then (after some processing) sends ...
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SaccadeAngular velocity Matlab

I have the data for a monkey's eye position in a cartesian plane synced to the time. I can convert the numbers into polar form however I'm not too sure how to find the angular velocity at that point. ...
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1answer
33 views

Neurophysiological mappings of empathy

What biologically plausible models are there of empathy? I know there has been a significant amount of work in defining emotion on a neurophysiological basis using models (I'm currently reading this ...
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1answer
40 views

Is cortical magnification in the visual system related to synaptic pruning, or is it a separate developmental or learning process?

I'm primarily interested in learning about current computational models that explain cortical magnification in the visual system. With this in mind, my specific questions are: (1) Is this phenomenon ...
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2answers
42 views

Are there models of single neurons on slow timescales?

From what I've come across on the web, most models of single neurons seem to focus on the "fast timescale", where electrical signals are transmitted from one neuron to another. However, neurons are ...
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1answer
162 views

How long does the trace of a memory last in the brain?

With long-term plasticity one refers to the phenomen by which synapses are modified by neural activity and these modifications last for long times, a day perhaps of the order of days. This phenomenon ...