For questions about the scientific study of the effects of pharmaceutical and general drugs on perception, behavior, mood and cognition.

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What is the Mechanism of 5-HT2A-mediated psychedelia?

Drugs that activate the serotonergic 5-HT2A receptor (e.g. LSD, psilocybin, mescaline) are notorious for causing psychedelic experiences and I would like to know the neurochemical mechanism behind ...
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Can SSRI make things worse in the long term or cause delayed depression?

I found these two articles that mention that taking SSRI for depression can actually make the depression worse. Is it true? Can Tardive Dysphoria (delayed depression) be caused by SSRI? ...