Questions tagged [neuroimaging]

For questions about techniques to directly or indirectly image the structure, function, or pharmacology of the brain.

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14 votes
2 answers
5k views

How do we know human brain development stops around age 25?

I've heard this stated as a fact more times than I can keep track of, but I haven't been able to find papers that actually demonstrate this. This seems to be the most cited paper on the topic, but it ...
0 votes
1 answer
85 views

"runs" or "sessions" in Structural MRI - Purpose and Implications for Quality Control

I am working on a graduate research project using the ABIDE I and II autism datasets. MRIQC has been run on these data - and I now must remove participants marked as outliers on 3 specific quality ...
3 votes
1 answer
45 views

Why do fNIRS devices commonly use two different frequencies?

One of the most common techniques used for functional neuroimaging nowadays is functional near infra-red spectroscopy (fun fact: IIRC Natalie Portman worked on a research paper involving fNIRS as the ...
0 votes
0 answers
7 views

automated co-registration of PET CT

Hi all:) I've acquired Whole body PET CT data from form which I would like to generate brain co-registered PET and CT nifti files - has anyone implemented something similar? I have experience with ...
1 vote
0 answers
26 views

Eddy Current Correction without reverse-phase encoding Data

I'm a beginner to dMRI analysis and am attempting to prepress data from the ABIDE-2 database (San Diego State Uni's DTI scan data) using the FSL pipeline (TOPUP->EDDY->DTIFIT). The TOPUP step ...
1 vote
0 answers
18 views

MNI vs. study-specific template in ABIDE ASD datasets

I'm new to MRI analysis and don't think I can properly gauge the implications to subsequent spatial analysis of performing registration to the MNI152 template. The form of analysis I'm conducting ...
0 votes
0 answers
20 views

Correlation of Gene Expression with Dynamic Imaging Phenotypes

I've been researching the process of performing a spatial correlation between gene expression in the brain and particular imaging phenotypes such as structural white matter connectivity. My research ...
0 votes
0 answers
8 views

How to estimate calcium concentration from fluorescence images

Is there a way to get a rough estimate of a [Ca2+] based on fluorescence microscopy images (obtained using GCaMP for example)? Usually what we get is the ratio f/f0, but is there a way to estimate the ...
1 vote
0 answers
57 views

Neuroimaging vs. Gene Expression for Neurological Disorders

As someone who has recently started learning about how we study the brain, the two most common forms of data I've encountered are neuroimaging data (fMRI scans, etc.) of the brain's distribution of ...
0 votes
0 answers
22 views

Interpreting Negative Z-Scores Gene Expression

When examining ISH heatmaps of gene expression in the brain, I'm typically looking for above-average expression in the form of high z-scores but have also encountered imaging with negative z-scores. ...
0 votes
0 answers
15 views

Time duration of the scanning (nifti file, .nii)

How to calculate/read the information about the time duration of the particular .nii file? Such information is not stored in the header (I checked the header with MATLAB niftiinfo function). Thanks! M
0 votes
0 answers
43 views

Error "File too small" When using spm_slice_vol, Fieldtrip MATLAB

When I was trying to convert a CT scan file's coordinate system into an approximation of the ACPC coordinate system on Fieldtrip MATLAB, there was error prompting that: ...
2 votes
1 answer
39 views

Seminal Books of fMRI

I would like to know what books about fMRI do people consider as key or seminal. I am very familiar with a great amonut of MRI techniques, but I am sort of looking for a book in fMRI that really ...
2 votes
1 answer
630 views

What is the difference between an Atlas and a Parcellation?

I come from a computer science background and am just starting out in the area of analyzing brain imaging data (fMRI predominantly) and while going through some of the literature, I am kind of ...
2 votes
0 answers
17 views

Question about How to assign the order of vertices of a pial surface in FreeSurfer

I'm a CIVET user but I recently started to use FreeSurfer. As far as I know, for a surface from CIVET, its vertices are ordered by upsampling a polygon. So I could access downsampled surface by ...
0 votes
0 answers
33 views

A tool to compare structural MRIs recorded at different times

I have two MRI's from the same person with a Huntington disease, recorded at different time points (with different MRI machines). I would like to compare the MRIs to see how the disease progresses. ...
0 votes
0 answers
15 views

why structural studies of the cerebellum (atrophy, segmentation, etc.) always reports LEFT and RIGHT even when laterality is absent from the study?

I have noticed that structural studies of the cerebellum, regardless of the focus of the study (neurodegenerative, autism, alcoholism, drummers) usually report left-sided and right-sided results. Even ...
3 votes
1 answer
3k views

How many possible states does a brain have?

Suppose I have a box, inside of which is a light which can be either on or off: it has exactly two states. Suppose I wanted to take some "snapshot" of the state of this device, and store all the ...
3 votes
1 answer
576 views

What does it mean if a neuron is "expressing" something?

Sorry for the simple question, not a neuroscientist just trying to understand a paper for school. In a study with mice, there was 2-photon calcium imaging done, and part of it read: We used single- ...
4 votes
1 answer
53 views

Does only the time-series data of fMRI matter or does spatial distribution of the signal values also matter?

I was denoising fMRI data using GLM and had a question regarding the “data” of fMRI in general. (For reference you can look at the “GLM” part of https://fmriprep.org/en/stable/outputs.html or https://...
4 votes
1 answer
79 views

BOLD->functional connectivity->spectral graph theory (e.g. Atasoy 2016) vs BOLD->Fourier Analysis

My read of "Human brain networks function in connectome-specific harmonic waves" (Atasoy 2016) seems to be that you can model brain activity in terms of standing waves of the connectome (...
6 votes
1 answer
627 views

What are the brain regions related to tinnitus shown in this figure?

I am interested in learning about the neural mechanisms behind tinnitus, and was wondering if someone could help me to name the parts of the brain on the image below from a site of the University ...
6 votes
2 answers
1k views

Is it possible to detect the mental flow state with EEG?

I know that it is possible to detect "focus" with a consumer EEG with a single electrode and a reference point (ear clip), even without conductive gel, but is it possible to detect a flow state with ...
0 votes
0 answers
62 views

Why memory studies was a strong area of research during 90's?

Memory studies seemed to have flourished during nineties - particularly early nineties. Not only in Psychology, but in neuroscience, in social sciences, in History, there was a period in which a lot ...
5 votes
0 answers
39 views

Why does Cross-sex hormone therapy have an opposite effect on cortical thickness?

In a recent lecture I was informed that cross-sex hormone therapy increases the cortical thickness in FtMs, but decreases CTh in MtFs. Why does this happen when studies find females have increased ...
1 vote
1 answer
694 views

Jung's Anima and Neurological Basis in Split-Brain Patients; Left-Persona and Right-Anima

So, having skimmed some studies on split-brain patients, it makes me wonder about the whole "left-brain/right-brain" dichotomy that made its rounds in public perception some time ago. I'm not sure ...
2 votes
0 answers
37 views

Cognitive impairment in fibromyalgia

People suffering from Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) often have memory and cognitive complaints. (Glass, 2006) In FM as in CFS, some abnormalities of cerebral blood flow have ...
0 votes
1 answer
20 views

What is the size limit of molecules entering the intracellular sections of a neuron?

As voltage sensitive organic dyes enter the inside of neurons and quantum dots are seeking to replace these due to their higher quantum yield, I was wondering what the seize limit is, as quantum dot ...
2 votes
1 answer
82 views

Measuring postsynaptic potential vs action potential at axon hillock?

I have been reading literature regarding Neuronal potential measurement. Conventionally, researchers use electrode-based method to measure action potential. However, as it's of high invasiveness and ...
1 vote
1 answer
25 views

Are there equivalent calcium imaging molecules that fluoresce in the presence of neurotransmitters between axons?

Molecules like GCaMP fluoresce when calcium ions attach to them. I was wondering if this can work with the other neurotransmitters in the brain or compounds that transmit signals outside of neurons.
0 votes
1 answer
33 views

How close are fluorescent dyes to individual neurons in two photon microscopy?

Considering the minute electrical excitation produced by neural cells needed to excite fluorescent dyes, how close are they to these cells, considering that being too close will disrupt cell processes....
2 votes
0 answers
232 views

Opening an aparc+aseg.nii.gz file programmatically in Python

How do you programmatically in Python open and read segmentation data in an aparc+aseg.nii.gz file programmatically? Is this correct? ...
3 votes
0 answers
47 views

Can the administration of self-report measures of craving prompt participants with addiction to experience craving during the experiment?

My research focuses on measuring the neural correlates (through resting-state EEG) pre-post an improvisational music therapy session (MT sessions) in clients with substance misuse. One of my variable ...
2 votes
0 answers
49 views

Is there any maping between the AAL to Brodmann areas (BA)?

I am trying to find any correspondence between BA6 (Premotor cortex) and AAL, but there are no information about it. Is there any equivalence table for Brodmann areas and other related anatomic labels?...
1 vote
0 answers
35 views

Has anyone tried using functional near-infrared spectropathy to quantitively measure sodium concentrations in the brain?

Functional near-infrared spectropathy "fNIRS", is a biophysics/medical technique that uses the near-infrared part of the electromagnetic spectrum (around 680nm to 810nm in wavelength) to ...
8 votes
1 answer
2k views

Frissons on demand

Have you ever listened to music and it gives you "chills?" This response is called a "frisson," a french word meaning "to shiver." When I want to access certain emotional and inspirationally charged ...
4 votes
0 answers
51 views

Do I report all anatomical regions in a large significant cluster identified in functional connectivity seed-to-voxel analysis?

I am conducting a resting-state functional connectivity seed-to-voxel analysis on the 25 participants from the NYC test-retest dataset using the CONN toolbox with the Posterior Cingulate Cortex of the ...
1 vote
0 answers
36 views

Choice of reference/mid-slice during SPM slice-timing-correction

I'm trying to figure out the simultaneous-multi-slice (SMS) factor for my MR acquisition, to use during slice-timing correction, in SPM12. The DICOM header obtained during conversion (with the ...
0 votes
0 answers
22 views

How firing of neurons stimulate reality? [duplicate]

Iam just an enthusiast.When I look for how does our brain works it boils down to firing of neurons in a pattern. I read that all of our thoughts, memory is due to firing of networks of neurons in a ...
1 vote
1 answer
89 views

Which characteristics of neural activity patterns underlie conscious experience?

Which specific characteristics of neural activity patterns are unique for the cortex and neocortex as the presumed "seat of consciousness" and can only be observed there? Activity patterns having ...
1 vote
0 answers
24 views

How well is biofeedback understood?

From an answer to the question Research suggesting conscious control over brain region activation? I have learned: »[S]ubjects become better at up-regulating or down-regulating activation in ...
2 votes
0 answers
389 views

Is there an equivalence table between the Desikan-Killiany atlas to brodmann areas?

FreeSurfer makes inferences about volume, through the calculation of the surface of the brain. The parametric method (used in SPM) is a voxel-based statistics. FreeSurfer analysis does not map the ...
0 votes
1 answer
381 views

What is the brain doing when someone tries to solve a physics or math problem that they can’t make any progress on?

Is their brain actually working or is it day dreaming and not functioning if they’re staring at a physics problem and not capable of making any progress on it? When a student who can’t come up with ...
0 votes
2 answers
154 views

Is what psychologists define as subconsciousness proven in neuroscience and can the psychological subconsciousness be visualized by neuroscientists?

We read phrases like The subconsciousness makes up 90% of our brain. The subconsciousness makes up 95% of our brain. The subconsciousness can be influenced by hypnosis. I have yet to see a study in ...
6 votes
1 answer
2k views

Are scintillating scotomas really caused by cortical spreading depression? If so, how is this known to be true?

I have just read about a visual effect called a scintillating scotoma. Many variations occur, but scintillating scotoma usually begins as a spot of flickering light near or in the center of the ...
2 votes
1 answer
81 views

Temporally truncate BOLD data

I'm analyzing some resting-state data and some of the scans are 10 min while others are 7 min. I need to cut the last 3 min off of those with 10 min scans so everyone has 7 min of resting-state data. ...
1 vote
2 answers
203 views

Does the duration of the epoch of interest in fMRI need to be a multiple of TR?

I am designing an fMRI experiment whereby, for each trial, subjects need to listen to an auditory stimulus (of arbitrary duration), and subsequently give a rating for each stimulus. I intend to ...
6 votes
0 answers
552 views

Supplementary Motor Area or Juxtapositional Lobule Cortex

Harvard-Oxford Cortical Structural Atlas now calls the 'Supplementary Motor Area' the 'Juxtapositional Lobule Cortex (formerly Supplementary Motor Cortex)'. I've looked for papers that explain the ...
1 vote
1 answer
394 views

Find volume of lesion mask

I have drawn a lesion mask using FSLeyes on a T1-weighted image for MS patients. Is there tool to get the lesion volume from the mask?
2 votes
1 answer
65 views

Publicly accessible database for the Autistic brain under MRI and/or fMRI

American neuroscientist James H. Fallon released many of the images of MRIs from diagnosed psychopaths and was able to identify a pattern when compared to the average individual. Is there a database ...