For questions about the biology of the nervous system, from a macroscopic to microscopic perspective.

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What is the importance of Dissociation (Both Double/Single) in a Distributed Hierarchical Organisational model of brain function?

How does Dissociation fir with a Hierarchical Organisational model Like Luria's or Distributed model of Fellman & Van Essen? Also, how may patients do you think should be the minimal amount in ...
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14 views

How common is it for twins conjoined at the head to share thoughts and visual stimuli?

I've always been interested in the possibility of a pair of conjoined twins, joined at the head, being able to read each other's thoughts, react to stimuli that one of them can't see/hear/feel, and ...
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1answer
27 views

What are 'gap junctions' (electrical synapses) for?

I was reading this and I found the following sentences: Apart from chemical synapses neurons can also be coupled by electrical synapses, so-called gap junctions. Specialized membrane proteins make ...
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2answers
375 views

How would synapses behave if resting potential was zero?

Assuming that the resting potential is zero and the other mechanisms were exactly the same, how would it affect the generation of spikes in terms of excitatory and inhibitory postsynaptic ...
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1answer
39 views

Could ketosis be therapeutic for ADHD based on the neuro-energetic theory of attention?

I'm a complete neuroscience novice so please bear with me. One of the more interesting theories of the etiology of ADHD that I've read posits that the disorder may be one of neuroenergetics - the ...
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What's the best model neural system for building and testing computational models? [closed]

I'd like to know which neural systems of the brain are relatively better understood, so that I can learn about it, and perhaps build a computational model of it. Since I have an affinity for computer ...
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1answer
74 views

Are the physical sensations of an emotion due to neural activity strictly in the brain or also in the body?

Symptoms of anxiety and anger are often described as some sort of energetic sensation in my chest and sometimes face or arms. Are these sensations an 'illusion' from neural activity strictly in the ...
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2answers
32 views

Are there models of single neurons on slow timescales?

From what I've come across on the web, most models of single neurons seem to focus on the "fast timescale", where electrical signals are transmitted from one neuron to another. However, neurons are ...
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1answer
24 views

Predictive Experiments on Neuroscience of Free Will

It seems to be very interesting that we can use modern neuroscience and cognitive science research to inform us about the ages-old question of free-will vs. determinism. The standard experiment was ...
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2answers
194 views

What is the neurobiological basis of the “inner voice” used for thought or reading?

I've recently experienced a number of hypnogogic near sleep states characterized by change in thinking (stage 1-2 sleep). I noticed that if I let go and get absorbed in the state, I can follow it. I ...
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1answer
154 views

Does adult neurogenesis occur only in the olfactory bulb and the hippocampus?

The scholarpedia article on this subject says: Adult neurogenesis is the process of generating new neurons which integrate into existing circuits after fetal and early postnatal development ...
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118 views

What is the result of an excess of dopamine?

I'm pretty familiar with the results of having not enough dopamine, though the reasons are not so clear to me. To get a better insight on the topic I'd like to know something about having too much ...
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Results from machine learning converging with results from neuroscience [closed]

I'm currently picking up deep learning, which is a trending method in the field of machine learning that have recently gained fame for breaking various records (for example in image recognition). It ...
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1answer
134 views

Why does strobe lighting trigger seizures in photosensitive epilepsy?

Photosensitive epilepsy (PSE) is a form of epilepsy in which seizures are triggered by visual stimuli that form patterns in time or space, such as flashing lights, bold, regular patterns, or ...
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1answer
76 views

How does it come about that specific areas of the brain are associated with specific functions?

During the development of the human brain, specific areas come to perform specific functions. How (and when) does this differentiation come about? Presumably, some areas of the brain naturally take ...
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1answer
45 views

Does synesthesia lack symmetry?

Some synesthetes report seeing bright flashes when hearing a loud noise. However, in the same person, bright flashes of light are not reported as being loud. I've read of other examples like this; ...
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125 views

Is there a difference between hearing and decoding the sound?

I presume that deafness is the inability of hearing any sounds. And I presume that it may also be possible to be less able to decode sounds. In other words, an inability to translate or understand the ...
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1answer
46 views

Can Transcranial Magnetic Stimulation (TMS), or a magnets cap make you smarter?

According to wikipedia, TMS is a bunch of magnetic fields directed to the brain which stimulates and activates neurons. If I wear a cap full of magnets, will it stimulate my neurons? If yes, will a ...
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29 views

Neurobiology of addiction recovery [closed]

While addiction is one of the most studied topics in neurobiology, I don't see very much info on recovery. The information I have found is confusing. This one says striatal DAT bindings return to ...
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25 views

How are psychological bio-markers discovered?

Recently, this paper claiming to be able to distinguish bipolar disorder from major depressive disorder via a urine sample has come to my attention. Despite reading the paper, I'm unable to ...
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1answer
38 views

Parasite that takes over cognitive functions [closed]

I am testing an idea for a book. The backbone of the story is that there exists a parasite that can enter the brain of a creature and take over its cognitive functions. I imagine that it could wire ...
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1answer
58 views

Are the human cerebral hemispheres only connected via the corpus callosum?

Are the human cerebral hemispheres only connected via the corpus callosum? Or is there any other structure for interaction between the left and right hemispheres?
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2answers
63 views

Are action potentials necessary for experience?

We know that, for example, during brain surgery, electrical stimulation in certain parts of the cortex is sufficient for experience, and result in reportable experiences in human subjects. We also ...
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89 views

What is the role of Chloride (Cl- ions) in membrane potential?

This Membrane Potential article mentions only that Cl- ion is used to model inhibitory GABA synapses. Does it have another role besides hyper-polarizing the cell due to inhibitory neurotransmitter ...
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2answers
116 views

How do neurons decide how to alter their output signals?

In computer science, neural networks are trained using backpropagation and other methods. Backpropagation heavily relies on mathematical formulas to describe how the weights should be changed ...
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1answer
46 views

Unified Theory of the Human Brain [closed]

I'm a junior researcher(Life Sciences undergraduate) starting out in computational genetics of neuroscience, and I want to create a Unified Theory/Computational Model of the human brain and all its ...
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89 views

Lifelong avoidance coping style [closed]

Suppose someone has been using avoidance coping style for most of his or her life. The avoidance tendency is present in a broad range of situations, relatively constant through his or her life, not ...
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2answers
137 views

Explanatory gaps in the formation and propagation of action potentials

To my understanding, the steps of an action potential are as follows: The neuron is at rest--there is a negative charge (K ions) inside the cell, and a positive charge (Na ions) outside the cell. ...
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1answer
97 views

How can pain sensations appear to originate within the person's skull?

I've read that humans have some sort of a kinesthetic model of their body and muscles. This internal representation of the body is used to control and coordinate locomotion. I don't remember if ...
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1answer
96 views

Is there a biological limit for “amount” of happiness?

I have heard about neurotransmitters like dopamin and serotonin that are supposed to play a role in our feeling of happiness. I don't know how these chemicals works in our brain, but I am thinking ...
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1answer
269 views

Does reading a book out loud make you better in social situations?

Suppose a person reads a book out loud for 1 hour straight. Would this "exercise" the parts of the brain involved in speech? Would this make the person a better communicator in social situations?
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What personality traits correlate with estrogen?

I'm looking for psychological traits that are proved to correlate with estrogen levels. Anything of specific behavior, attitudes, life styles, emotions, preferences, you name it. (I'm looking for ...
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2answers
67 views

Result of local stimulation in brain

What happens when we stimulate a brain in local regions? Some possibilities: We may trigger an action without the subject's awareness of the action; We can trigger an action in a subject, but we ...
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How does oxygen deprivation affect neural activity?

It is increasingly common for someone to regain a heartbeat after a cardiac arrest. During the time that the person is without a heartbeat, and so without circulation, the brain is deprived of oxygen. ...
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What exactly is an astroglial calcium wave?

There are quite a few conflicting reports as to what stimulates them, how they propagate, whether they communicate intercellularly, and what they look like. The only consistent information I can ...
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4answers
146 views

If a human brain would be placed inside that of an animal: Could it talk?

Assumption: Animals can't talk 'human' because of their small(er) brain. Perhaps a strange thought, but I was really wondering: If we could place a human brain inside that of an animal: Would we be ...
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1answer
59 views

What is the neurophysiological mechanism behind double hearing?

A patient with sensorineural hearing loss can have the symptom of hearing "double" in the damaged ear. Not having a time-delayed echo, but hearing as if he (or other people) speak with "two voices" at ...
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3answers
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What are current neuronal explanations and models of 'consciousness'?

I would like to understand more about consciousness from a neuroscientific perspective. I have a limited understanding of it in the philosophical/psychological sense through lectures. Although it is ...
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127 views

Are the center surround receptive fields learnt or inherited?

I know that neurons higher in visual pathways can learn their receptive fields after birth, but what about the connections between bipolar cells and Amacarine cells which form center/surround on/off ...
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1answer
39 views

Classical conditioning paradigm for hippocampal learning

I wanted to know what a suitable classical conditioning experiment would be to analyze learning and memory capabilities in rodent models with respect to hippocampal long-term potentiation (LTP). For ...
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1answer
56 views

What are the highest ranked neuroscience journals that use double-blind review process?

In terms of impact factor (for a lack of a better proxy), what are the highest ranked neuroscience journals that use double-blind review process? I would be submitting a paper that combines ...
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2answers
81 views

How many action potentials from presynaptic neurons would be required to make a postsynaptic neuron fire?

I am looking for a rough estimation of the number of action potentials from other neurons required to cause a neuron to fire? I read here that a potential of ~ -55mv must be reached before an action ...
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1answer
93 views

How similar are the brains of twins?

I am currently reading undergraduate essays on biological dysfunction and schizophrenia. The students put a lot of weight in the fact that studies of monozygotic twins show only a 50% rate of ...
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1answer
95 views

Why is the order of white/grey matter different in the brain and spinal cord?

In the brain proper, grey matter forms the outer layer of the brain, and white matter forms the inner layer. In the spine, this is reversed: white matter forms the outer layer of the spine, and grey ...
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3answers
793 views

In what ways can neurons fire randomly?

When developing a model of a biologically-plausible neural network, it is important to know all the circumstances under which neurons can fire. But, I am limiting this question to random firing. In ...
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70 views

Have any drugs been shown to increase the neuroplasticity of adult brains?

I read recently in the book "meet your happy chemicals" that the hormones of puberty are neurochemicals that cause your neurons to connect and myelinate more easily. If this is true have any studies ...
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1answer
92 views

Comparative functional neuroanatomy: humans & octopodes

Cephalopod brains are toroidal (high surface area to volume ratios!), with the esophagus passing through the, uh, donut hole; octopodes are very intelligent, particularly spatially. Where can I find ...
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1answer
272 views

Can stress or training influence the perception of time?

I have had this experience that I fell with my bike on an icy street. During the fall time seemed to slow down and I had an apparent age-long time window to stretch my hand and safely catch my fall. ...
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1answer
221 views

What explains variability in the mean firing rate across biological neurons?

Biological neurons have a trade-off between high information transfer (high firing rate) and energy conservation (low firing rate). One would suspect that the maximization of this function has a ...
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65 views

Does an action potential abolish an excitatory postsynaptic potential?

From some sources, I've read that excitatory postsynaptic potentials (EPSPs) decay over time, which would imply that they aren't abolished by action potentials. However, other sources seem to indicate ...