For questions about the biology of the nervous system, from a macroscopic to microscopic perspective.

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2answers
84 views

Are action potentials necessary for experience?

We know that, for example, during brain surgery, electrical stimulation in certain parts of the cortex is sufficient for experience, and result in reportable experiences in human subjects. We also ...
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2answers
2k views

What is the role of Chloride (Cl- ions) in membrane potential?

This Membrane Potential article mentions only that Cl- ion is used to model inhibitory GABA synapses. Does it have another role besides hyper-polarizing the cell due to inhibitory neurotransmitter ...
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2answers
186 views

How do neurons decide how to alter their output signals?

In computer science, neural networks are trained using backpropagation and other methods. Backpropagation heavily relies on mathematical formulas to describe how the weights should be changed ...
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1answer
56 views

Unified Theory of the Human Brain [closed]

I'm a junior researcher(Life Sciences undergraduate) starting out in computational genetics of neuroscience, and I want to create a Unified Theory/Computational Model of the human brain and all its ...
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0answers
111 views

Lifelong avoidance coping style [closed]

Suppose someone has been using avoidance coping style for most of his or her life. The avoidance tendency is present in a broad range of situations, relatively constant through his or her life, not ...
2
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2answers
402 views

Explanatory gaps in the formation and propagation of action potentials

To my understanding, the steps of an action potential are as follows: The neuron is at rest--there is a negative charge (K ions) inside the cell, and a positive charge (Na ions) outside the cell. ...
3
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1answer
100 views

How can pain sensations appear to originate within the person's skull?

I've read that humans have some sort of a kinesthetic model of their body and muscles. This internal representation of the body is used to control and coordinate locomotion. I don't remember if ...
5
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1answer
162 views

Is there a biological limit for “amount” of happiness?

I have heard about neurotransmitters like dopamin and serotonin that are supposed to play a role in our feeling of happiness. I don't know how these chemicals works in our brain, but I am thinking ...
3
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1answer
337 views

Does reading a book out loud make you better in social situations?

Suppose a person reads a book out loud for 1 hour straight. Would this "exercise" the parts of the brain involved in speech? Would this make the person a better communicator in social situations?
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0answers
58 views

What personality traits correlate with estrogen? [closed]

I'm looking for psychological traits that are proved to correlate with estrogen levels. Anything of specific behavior, attitudes, life styles, emotions, preferences, you name it. (I'm looking for ...
3
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2answers
71 views

Result of local stimulation in brain

What happens when we stimulate a brain in local regions? Some possibilities: We may trigger an action without the subject's awareness of the action; We can trigger an action in a subject, but we ...
4
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0answers
39 views

How does oxygen deprivation affect neural activity?

It is increasingly common for someone to regain a heartbeat after a cardiac arrest. During the time that the person is without a heartbeat, and so without circulation, the brain is deprived of oxygen. ...
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0answers
54 views

What exactly is an astroglial calcium wave?

There are quite a few conflicting reports as to what stimulates them, how they propagate, whether they communicate intercellularly, and what they look like. The only consistent information I can ...
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4answers
215 views

If a human brain would be placed inside that of an animal: Could it talk?

Assumption: Animals can't talk 'human' because of their small(er) brain. Perhaps a strange thought, but I was really wondering: If we could place a human brain inside that of an animal: Would we be ...
6
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1answer
133 views

What is the neurophysiological mechanism behind double hearing?

A patient with sensorineural hearing loss can have the symptom of hearing "double" in the damaged ear. Not having a time-delayed echo, but hearing as if he (or other people) speak with "two voices" at ...
33
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3answers
1k views

What are current neuronal explanations and models of 'consciousness'?

I would like to understand more about consciousness from a neuroscientific perspective. I have a limited understanding of it in the philosophical/psychological sense through lectures. Although it is ...
10
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1answer
144 views

Are the center surround receptive fields learnt or inherited?

I know that neurons higher in visual pathways can learn their receptive fields after birth, but what about the connections between bipolar cells and Amacarine cells which form center/surround on/off ...
7
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1answer
47 views

Classical conditioning paradigm for hippocampal learning

I wanted to know what a suitable classical conditioning experiment would be to analyze learning and memory capabilities in rodent models with respect to hippocampal long-term potentiation (LTP). For ...
3
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1answer
71 views

What are the highest ranked neuroscience journals that use double-blind review process?

In terms of impact factor (for a lack of a better proxy), what are the highest ranked neuroscience journals that use double-blind review process? I would be submitting a paper that combines ...
2
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2answers
108 views

How many action potentials from presynaptic neurons would be required to make a postsynaptic neuron fire?

I am looking for a rough estimation of the number of action potentials from other neurons required to cause a neuron to fire? I read here that a potential of ~ -55mv must be reached before an action ...
8
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1answer
124 views

How similar are the brains of twins?

I am currently reading undergraduate essays on biological dysfunction and schizophrenia. The students put a lot of weight in the fact that studies of monozygotic twins show only a 50% rate of ...
12
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3answers
1k views

In what ways can neurons fire randomly?

When developing a model of a biologically-plausible neural network, it is important to know all the circumstances under which neurons can fire. But, I am limiting this question to random firing. In ...
4
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0answers
102 views

Have any drugs been shown to increase the neuroplasticity of adult brains?

I read recently in the book "meet your happy chemicals" that the hormones of puberty are neurochemicals that cause your neurons to connect and myelinate more easily. If this is true have any studies ...
8
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1answer
99 views

Comparative functional neuroanatomy: humans & octopodes

Cephalopod brains are toroidal (high surface area to volume ratios!), with the esophagus passing through the, uh, donut hole; octopodes are very intelligent, particularly spatially. Where can I find ...
12
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1answer
235 views

What explains variability in the mean firing rate across biological neurons?

Biological neurons have a trade-off between high information transfer (high firing rate) and energy conservation (low firing rate). One would suspect that the maximization of this function has a ...
9
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1answer
74 views

Does an action potential abolish an excitatory postsynaptic potential?

From some sources, I've read that excitatory postsynaptic potentials (EPSPs) decay over time, which would imply that they aren't abolished by action potentials. However, other sources seem to indicate ...
8
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1answer
205 views

Why is it easier to fall asleep in the dark?

I'm curious if there is any neurological mechanism that explains why falling asleep is easier in the dark. I recognize that this isn't true universally -- a phobia of darkness might make it easier to ...
3
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1answer
95 views

What is the neurobiological difference between Jungian Judging and Perceiving individual?

Jungian or Myers Briggs type indicator reserves the last letter of a 4 letter archetype to stand for Judging or Perceiving. Part of being a Judging type is punctuality - being on time, keeping ...
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2answers
175 views

Which are the multisensory brain areas?

What would be an example of a multisensory brain area, where multiple senses (e.g. smell and taste) are combined to decode the corresponding stimuli from more than one sensory organ? I was thinking ...
7
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1answer
222 views

Can prolonged neural adaptation lead to HPPD?

The human brain adapts to a constant stimulus of our neural system. For instance, if we ride a train and look out of the window for a long time and the train stops, we have the feeling of slowly ...
11
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2answers
829 views

What is the “static” in human vision called?

Sort of like a cheap digital Camera, the human eye has certain feedback that's perceived but doesn't actually exist in the real world; a little layer of Static that's especially noticeable in pitch ...
3
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1answer
57 views

Is the weight of neural inputs in the human brain as central as it is for neurons in an artifical neural network?

As an example of an artificial neural net (ANN), a neural processing unit (NPU) is able to encode previous (learned) information by storing a weighted resistance for each input. Since ANN's are ...
4
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1answer
284 views

Why do some people stutter only when they are nervous?

Background: I don't stutter at least not always. For example, if I be reading out a article to myself, It is sure that I will not stutter even that I am reading it out loud. The times when I do ...
5
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0answers
41 views

Is movement/activity level related to serotonin availability or reuptake rates in the brain?

I'm aware of this research article that explores the relationship between motion and serotonin systems: 5-HT and motor control: a hypothesis. Based on the article above, it seems to me that a "very ...
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1answer
71 views

What is so “potential” about action potentials?

When an action potential is propagating through a neuron, it seems to me that the time for "potential of action" is over, and that we are now just in a state of "action". Why don't we just call action ...
5
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1answer
115 views

Do widespread brain toxins explain violence rates?

Saw this: http://www.motherjones.com/environment/2013/01/lead-crime-link-gasoline Lead emissions from tailpipes rose steadily from the early '40s through the early '70s, nearly quadrupling over ...
5
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1answer
430 views

What's the difference between executive functions and cognitive control?

I suspect that the difference between these terms may vary from researcher to researcher, since the wikipedia page treats them as synonymous. What's the difference between executive functioning and ...
3
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1answer
115 views

What are the neurobiological factors related to depression?

While it is agreed that neurotransmitters aren't the primary "cause" of depression, what other factors are a part of this mental illness that focus on the neurobiological aspects of it?
6
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1answer
308 views

How are qualia localized in consciousness?

I understand that evolution incorporated arbitrary qualia into the default network to inform consciousness (the largest cranial global processing information subnetwork) about properties and qualities ...
5
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1answer
90 views

Difference in frequencies of mistakes between use of left-right vs. up-down

I have no hard data, but from my personal experience in people specifying right or left directions (similarly east or west) and up or down (north or south, top or bottom), people frequently make ...
3
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1answer
55 views

How does Parkinson's disease result in tremors?

From what I understand, Parkinson's disease is caused by the death of dopamine producing cells in the substantia nigra, however I don't understand how that causses the symptoms of Parkinson's. I am ...
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0answers
139 views

What are the brain regions related to tinnitus shown in this figure?

I am interested in learning about the neural mechanisms behind tinnitus, and was wondering if someone could help me to name the parts of the brain on this image that show increased activity in ...
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3answers
1k views

What do the super-large brains of whales and elephants map to?

Elephants and whales have brains that are much larger than those of humans. It is presumed that much of their brain is used up for their larger bodies (after all, there is a allometric scaling between ...
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0answers
44 views

Psychological problem with glasses and hats on head? [closed]

I knew a kid who, when they was little, they would have attacks when a relative removed their glasses. She would sometimes do it on purpose in front of them and they would have emotional outbursts ...
6
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1answer
110 views

Visual acuity and offset stimuli

I'm currently setting up and experiment that utilises a visual search task that contains a circular array of target letters and a distractor that falls outside the circle. Obviously the further away ...
3
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0answers
94 views

What are the smallest neurons ever identified? [closed]

What are the smallest neurons ever measured? I'm happy with any superlatives, such as the thinnest axons or dendrites, smallest somata etc. Thank you :)
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2answers
340 views

How do SSRIs work?

I've found a reasonable explanation on Wikipedia... SSRIs are believed to increase the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, ...
2
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1answer
40 views

Determining the position of the calcium ion in the three dimensional space

Is it possible to determine the position of a single calcium ion or its population in the context of a three dimensional space with relatively good time frequency, say 1 Hz, taking into account ...
5
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0answers
41 views

How does de-myelination occur in multiple sclerosis? [closed]

From what I understand, only the oligodendrocytes are affected in multiple sclerosis, and they are attacked by T cells which cross the blood-brain barrier. This leads me to two questions: How is the ...
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2answers
159 views

Long term effect of using noise generators

Some people use noise generators as http://playnoise.com/ to reduce distraction by background noise. Is there any research on the long term effects of this? Does this affect the neuronal connections ...