For questions about the biology of the nervous system, from a macroscopic to microscopic perspective.

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How long does zebrafish remain transparent?

As larva, zebrafish is transparent, at least tip 5-6 days. I wonder what would be the upper limit age for such transparity, considering for purpose of imaging. (For normal zebrafish, not special ...
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How does my spinal cord know to take reflexive action?

As in, how does my body know that a stove is not hot enough to warrant a reflex? Is it because there isn't a sudden electrical surge going through the nervous system?
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Explanatory gaps in the formation and propagation of action potentials

To my understanding, the steps of an action potential are as follows: The neuron is at rest--there is a negative charge (K ions) inside the cell, and a positive charge (Na ions) outside the cell. ...
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What is so “potential” about action potentials?

When an action potential is propagating through a neuron, it seems to me that the time for "potential of action" is over, and that we are now just in a state of "action". Why don't we just call action ...
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Do studies exist that can map specimens of neocortex to the functions they perform(ed) in vivo?

Much brain research has proposed that the brain (the neocortex, esp.) is set up in areas - an area for faces, an area for language, etc.. The experiments typically go 1) damage an area 2) observe ...
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How many dendrite connections vs axon terminals does a multipolar cerebral neuron have?

I find countless places that say neurons have tens of thousands of "connections" or "synapses" and one axon. Do neurons have tens of thousands of dendrite connections, and a few axon terminals; or a ...
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Role of white blood cell inside brain

Inside brain, Microglia cell is responsible for phagocytosis. It seems that brain can function properly without white blood cell. Also according to my research white blood can be hazardous to brain as ...
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1answer
34 views

Can fMRI and EEG signals be generated from NEF models?

The basic function of the NEF is to map the outside world onto neurons, using the firing rates of the neurons. It also supports various neuron models. Have these firing rates been used to create EEG ...
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1answer
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Benefits of using more complicated neuron models in NEF models

The NEF allows you to use almost any neuron model as long as it has an equation for it's activity and it's spikes in some way. Usually, a simple leaky-integrate-fire (LIF) neuron model is used, but ...
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1answer
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What is the difference between a biological and behaviorist perspective in psychology?

I was recently reading through a textbook and was unable to clearly identify the differences between the two due to a vague definition of both. Can someone provide an in-depth explanation of the two ...
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How can we analyse user behavior to predict urge of smoking?

The problem which I want to target is to be able to successfully predict (to a degree) that a person is going to smoke in near future. I want to look at the relationship between chemical reactions ...
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How can we use EEG data to predict urge of smoking?

I am from Computer Sciences background. The problem which I want to target is to be able to successfully predict (to a degree) that a person is going to smoke in near future. I have a brainwave ...
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1answer
38 views

Regarding the mind and what it can affect

About the question 'Can the mind mind affect the brain?': Some responses are 'no' because the mind is a physical 'thing' or structure (if I read it correctly). Yet if the Mind is only a physical ...
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1answer
40 views

What are presynaptic puncta?

What are presynaptic puncta? And what makes them different from presynaptic terminals?
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1answer
33 views

Visual acuity and offset stimuli

I'm currently setting up and experiment that utilises a visual search task that contains a circular array of target letters and a distractor that falls outside the circle. Obviously the further away ...
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25 views

Are there parts of the brain which don't change over a lifetime?

We know that during our lifetime the brain develops new neural connections and also there is pruning of neural connections. These phenomena together are called neuroplasticity. Is there any research ...
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1answer
61 views

Why do some people stutter only when they are nervous?

Background: I don't stutter at least not always. For example, if I be reading out a article to myself, It is sure that I will not stutter even that I am reading it out loud. The times when I do ...
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260 views

What is the difference between pre-synaptic versus post-synaptic?

I am unclear as to the exact meaning of the terms pre-synaptic and post-synaptic. Specifically, do they refer to the same neuron, either transmitting or receiving, before and after the chemical ...
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58 views

Do the colour blind have a distinct visual cortex structure?

Studying the structure of the visual cortex, it seems there are many neural structures specifically dedicated to detecting and interpreting colour. For example, parvocellular cells are particularly ...
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1answer
47 views

How to filter noise in EEG data

I am a computer science student and I'm doing something for a psychology professor. We have EEG data from an experiment where a person was shown 140 images for 2 seconds each. We placed 64 electrodes ...
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What chemical or neurological mechanism causes the feeling of fulfillment?

We all know that someone can find intense pleasure in something without finding it fulfilling. But what causes our feeling of fulfillment? If I knew what it was, I could be more fulfilled and ...
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42 views

Grid cells : Between what is the correlation of autocorrelogram measured?

In their seminal paper Hafting, Torkel, et al. "Microstructure of a spatial map in the entorhinal cortex." Nature 436.7052 (2005): 801-806.‏ the Mosers have discovered the grid cells. To show the ...
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1answer
68 views

What is the biological reason behind disorganized thinking and disorganized behavior in thought disorders?

Having disorganized thinking is different for everyone. But, it is sometimes described as not being able to connect thoughts together. I am asking about disorganized thinking other than communication ...
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What is the result of an excess of dopamine?

I'm pretty familiar with the results of having not enough dopamine, though the reasons are not so clear to me. To get a better insight on the topic I'd like to know something about having too much ...
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What neurotransmitters can be suppressed/promoted by tDCS

Transcranial Direct Current Stimulation (tDCS) has been shown to modify suppression in the visual cortex and GABA suppression in motor control. As of now, the exact neurobiological mechanism that ...
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1answer
64 views

Is meaning-seeking behavior a biological optimization problem?

In short, I'm interested in cognitive, neuroscientific, biological and/or computational perspectives on what we vaguely refer to as meaning seeking. Of course, this is a large topic, but any ...
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Physiological mapping of frustration

What physiological changes are seen in the brain when a person is experiencing frustration? What effects do these changes have on learning? Optional background: I'm trying to figure out an ...
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109 views

Is there a report of a successfully EEG-Based Brain-Computer Interface (BCI) using image training?

Currently I am involved in constructing an EEG-Based BCI. The goal of the BCI is to control which light in a series of lightbulbs lights up. The plan is to use different images (i.e. a flower versus ...
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104 views

What is the neurobiological basis of the “inner voice” used for thought or reading?

I've recently experienced a number of hypnogogic near sleep states characterized by change in thinking (stage 1-2 sleep). I noticed that if I let go and get absorbed in the state, I can follow it. I ...
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What is the neurobiological difference between Jungian Judging and Perceiving individual?

Jungian or Myers Briggs type indicator reserves the last letter of a 4 letter archetype to stand for Judging or Perceiving. Part of being a Judging type is punctuality - being on time, keeping ...
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1answer
33 views

How do we localize pain?

I know that different points of the brain correspond to different point of the body. But how a sensory information reaches its correct corresponding area? For example, let say I put a pencil's ...
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25 views

What ways can STEM teaching change in USA to accommodate social needs of females?

Brizendine seems to point to the female brain as a handicap for STEM education due to the typical female's need for communication and sociability because of their estrogen needs eschew solitary ...
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1answer
58 views

What is runaway excitation?

Can someone give me a brief explanation of this term? Found it in a paper but there doesn't seem to be an explanation that is consistent out there to my knowledge.
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Perforated patches: Can antibiotics used to induce holes in membrane produce perforations of differential size?

Perforated patches are a special type of patch clamping. I understand that it is sometimes preferred to whole-cell recordings because it prevents complete diffusion of the electrode solution into the ...
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How does neurotransmitter distribution and usage vary thought the brain?

I understand that neurotransmitters are used to send signals between neurons in the brain and that some are used for rather specific functions. However, is the exact ...
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1answer
28 views

What is the relationship between neurotransmitter release and resting potential in retinal bipolar cells?

Retinal bipolar cells are known to have resting potentials from which they can become more or less polarized. What I'm wondering is whether a bipolar cell's neurotransmitter-release rate is zero when ...
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Determining the position of the calcium ion in the three dimensional space

Is it possible to determine the position of a single calcium ion or its population in the context of a three dimensional space with relatively good time frequency, say 1 Hz, taking into account ...
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1answer
38 views

Is cortisol an effective measure of stress for pre and post task performance?

I have a teleoperation system and I want to see how much stress a person is under before during and after operating it. I thought cortisol would be a correlate of stress. Can I measure levels rapidly, ...
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Do all humans have some amount of prions?

I understand that some humans can have prions that develop into neural diseases, but do all of us have at least some amount of prions in our bodies, and more specifically our brains?
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1answer
73 views

Brain after (electrical) blackout

I was wondering what happens if we lose all electrical impulses in our nervous system for a minimum amount of time. So first of all it is obvious that we will break together, as we are dead while we ...
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2answers
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What background is required to understand the book “Principles of Neural Science”?

What is the necessary background to read this book and comprehend it? I've taken Calc I-II, Chem 1A and Bio 1A. Is this enough?
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1answer
65 views

Evolutionary motivation for the existence of pleasure

Firstly, I'd like to understand, what exactly is pleasure? If we presume we are streams of thoughts, thoughts being neurons activated in some pattern, and that basically anything what the conscience ...
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2answers
137 views

The psychology of nymphomania

So this is a question that requires maturity and discretion. I present it as an authentic point of research for a class I am taking. I understand the basic principles of mania, psychomania, and ...
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2answers
152 views

Why does a neuron choose to connect to another?

I have been reading about neuron creation, guidance cues and all sorts of highly complex mechanisms used to allow one neuron axon to extend or connect - but to what end? Why does one neuron end up ...
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Neuropharmacology and Simulation

I've been wondering whether neural simulations have had applications in (cognitive)neuropharmacological research already. One always reads about the promise of the technology in helping us cure ...
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2answers
204 views

Why is MATLAB so common in Neuroscience?

It is common knowledge that neuroscience -- particularly experimental neuroscience -- uses MATLAB more than any other programming language. I have always just taken this as a given, and pointed to ...
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38 views

How many action potentials from presynaptic neurons would be required to make a postsynaptic neuron fire?

I am looking for a rough estimation of the number of action potentials from other neurons required to cause a neuron to fire? I read here that a potential of ~ -55mv must be reached before an action ...
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2answers
55 views

Are there any serious neuroscientific theories of emotional valence?

Could anyone tell me if there are any serious neuroscientific mechanisms that have been proposed to explain how feelings of body states take on a positive or negative character (valence)? An example ...
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1answer
73 views

Where in the brain is meaning extracted from visual information?

I am looking into several systems for improving learning speeds and ran into a question I seem unable to answer on my own: When we read a word, it somehow gets converted into it's abstract meaning. ...
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Number of presynaptic inputs per cell in primary visual cortex

I have been digging in the literature lately, but I haven't found a nice answer with clear cut numbers (avg +- std) to this question: How many presynaptic inputs receives a pyramidal cell in primary ...