Early symptoms of Alzheimer’s disease (AD) includes the loss of short term memory including prospective memory. On a physical level brain cells are being destroyed and that disrupts the neural pathways that form memory.
My interest is on cognitive remediation programs that use spaced repetition (spacing effect/spaced retrieval/gradual interval recall). A Google scholar search http://scholar.google.com/scholar?q=%22spacing+effect%22+Alzheimer%27s&btnG=&hl=en&as_sdt=0%2C5&as_ylo=2000 lists many papers that show a positive effect but I don't know how to search for what is happening at a physical level?
Can someone describe the effect at the physical level?
In the book "The Foundations of Remembering: Essays in Honor of Henry L. Roediger, III" page 95:
Camp and colleagues have argued that expanded retrieval training makes use of implicit memory, which is relatively spared even in the later stages of AD
What is implicit memory and why is it not affected by AD until late stages?