Take the 2-minute tour ×
Cognitive Sciences Stack Exchange is a question and answer site for practitioners, researchers, and students in cognitive science, psychology, neuroscience, and psychiatry. It's 100% free, no registration required.

I know there is synaptic plasticity in the mature brain. There is a great number of plasticity mechanisms like LTD and LTP, acting on different time scales. Apart from the synaptic weight change, there is constant rewiring. New spines are being born, those who find a synaptic bouton can even expel the previously connected spine to that bouton.

What I don't know is the specific time constant associated with the rewiring. I also don't know the net effect of this plasticity. What is the average lifetime of the synapse? What percent of the synapses are rewired, say, in a day? The motivation behind my question is to understand, how volatile is the brain and how fast does it change. For example, are my distant memories of childhood written in the synapses that never changed since their creation or have they been already rewritten several times?

I understand that the answer depends on the species, brain area and type of activity. Ideally it would be , say, human broca's area in normal lifestyle. But I'll be happy to know answers for other circumstances as well.

share|improve this question
add comment

1 Answer 1

up vote 4 down vote accepted

In adult mouse cortex, synaptic spines can last anywhere from days to months.

I'm not sure that any such work has been done on human Broca's area, but keep in mind that many synapses are experience dependent. One study found that fear conditioning and fear extinction lead, respectively, to synapse formation and elimination. So the lifetime of a synapse could depend largely on environmental conditions.

share|improve this answer
    
Is there similar study in the primates? Mice only last for year, so it would be interesting to know the lifetime of synapse in longer living species. –  neuronich Jan 16 at 1:05
add comment

Your Answer

 
discard

By posting your answer, you agree to the privacy policy and terms of service.

Not the answer you're looking for? Browse other questions tagged or ask your own question.