Psychotroph substances assume to have a lot of potential.
Due they where banned pretty soon after their appearance in western culture, we know almost nothing about them. In some cultures there is a large knowledge about spiritual usage, but as it is in cultural things, near to none scientific research.
In the UK they started research in the 1990s and it seems like LSD/Psylocibin (which seem to have nearby exact the same effect on our brain) can be used to tread phobia and psychcological traumata in manifold issues.
Albert Hofmann(who discovered LSD) said, LSD would not alter the consciousness but expand it. Like an catalystic converter wich is needet to use the full potential of our consciousness.
In his book "LSD - Mein Sorgenkind" he wrote that the things a proband sees are not hallucination but input to his sensory organ which he doesn't know and wich might overexcite him.
This catches up with expirienced users of such drugs(multiple 10 times to over 100 uses), wich tell that the chance of horrortrips lowered with every usage and also they gained the abillity to "controll" their expirience in some form.
Beside of this, there are many artists wich tell that their creativity expand under influence of LSD, and even a single use in lifetime had expand the creativity.
It's assumed that depressive people have a high chance to better their condition. But the chance of horrortrips, even if this chance is really low, is a too high risk to use it in that issue.