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Loneliness can be debilitating, and the feelings associated with it can be overwhelming, including feeling 'cold inside', sad, hopeless and even helpless.

Many things can 'cause' loneliness', both real and perceived, but what I am interested in is not the causes, but the neurological mechanisms that cause the feelings associated with loneliness.

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closed as too broad by Christiaan, Arnon Weinberg, huh, Robin Kramer, Krysta Jul 5 at 12:47

There are either too many possible answers, or good answers would be too long for this format. Please add details to narrow the answer set or to isolate an issue that can be answered in a few paragraphs.If this question can be reworded to fit the rules in the help center, please edit the question.