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Given that Long Term Potentiation (LTP) is the process of improving synaptic efficacy.

Given that within a lab, the strength and repetition of stimulus on the brain can be linked with the priming of the synapses, and improving efficacy, with LTP.

This question combines the following ideas:

Given what we know at this point, can a link be established between intensity and repetition of brain stimulations and physical changes to the brain?

Would it be possible to quantify a range of "experiences", perhaps there could be a scale upon which experiences can be placed with propensity to create changes within the brain.

Permitting a bit of reductionist thinking for a moment, we can theorize that all thought, personality and human behaviour is somehow connected to the underlying biology. So I would suggest that any experience (or series of experiences) that has a long term effect on synaptic efficacy could be linked with changes in behaviour and/or personality (or vice versa). This would be a useful aide in Cognitive Behavioural Therapy.

Within the context of this proposition, I am asking can underlying cellular changes be categorised and ranked as to the effectiveness as stimulators for personality, behavioural, or cognitive changes (whether such changes are beneficial or otherwise), using a neurological and behavioural approach.

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You mean electrophysiologically? Can you clarify? – Memming Aug 7 '13 at 18:38
What do you mean exactly by the "efficacy of LTP"? Also, why are you only focusing on potentiation and not depression (in general plasticity)? Are you planning to specifically measure LTP? In early sensory areas where you can reliably evoke action potentials with stimuli perhaps it is possible to say it is causal, but in higher order areas causal relationships of this sort is not clear. LTP in which area on what kind of task are you talking about? All LTPs in the brain??? (also there's a typo in the title) – Memming Aug 7 '13 at 20:43
I agree with @Memming, this is very confusing. How would you ever measure it in humans? – Chuck Sherrington Aug 8 '13 at 4:34
The question is improved. Yes, there are numerous animal studies that show stimulus induced plasticity often with changes in behavior. The question is still broad for me to answer specifically, though. IMHO, neuroscience have not yet achieved understanding at the level applicable to complex cognitive and personality level. Most of these tasks are very elementary perceptual/decision-making related, and I wouldn't draw any conclusions from them for therapy. – Memming Aug 9 '13 at 12:19
I think the title should be edited to better reflect the body of the question. As it stands the title suggests a question similar to this one but the body suggests something completely different. – Artem Kaznatcheev Dec 4 '13 at 17:39

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