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Drugs that activate the serotonergic 5-HT2A receptor (e.g. LSD, psilocybin, mescaline) are notorious for causing psychedelic experiences and I would like to know the neurochemical mechanism behind this.

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Not sure if this answers your question satisfactorily but the reason for the psychedelic state is "broadband cortical desynchronization"

http://www.jneurosci.org/content/33/38/15171.short

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Any chance you could expand on this answer? It's rather a stub, but it's right enough that I don't feel like giving an independent answer unless I have to. –  Christian Hummeluhr Mar 22 at 11:28
    
I'm pretty busy at the moment..you could use my source and write a better answer..I will then delete mine.. –  Mike Schärer Mar 23 at 14:10

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