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I'm interested in this area because, there is far less monoamines neurotransmitters based neurones than based on amino acid neurotransmitters. So it seems that monoamines based system is fine tuning work of the whole system while, amino acid neurotransmitters based neurons are the work hourse.

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Just curious, the wikipedia entry on the evolution of monoamine neurotransmitters links to this article; is it useful? Lövheim, Hugo (2012). "A new three-dimensional model for emotions and monoamine neurotransmitters". Medical Hypotheses 78 (2): 341–8. doi:10.1016/j.mehy.2011.11.016. PMID 22153577. –  Jeromy Anglim Apr 17 '13 at 11:17
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An interesting question. Some type of receptor-mediated membrane potential regulation probably can be found in single-cell eukaryotes, but I don't have a reference for that. –  Chuck Sherrington Apr 17 '13 at 22:58
    
@Chuck Sherrington interesting thanks –  Qbik Apr 18 '13 at 12:39
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This might be more appropriate for biology.SE. –  Memming Apr 18 '13 at 15:45

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